I just think that having the Smiths fighting side-by-side strips down what was interesting about Killer7 into a sort of TDM with a TFC-range of character classes. Yeah, it would be fun to shoot invisible, laughing enemies with a limited range of weapons (hopefully upgradable in some way between rounds, as well as the blood powerups from killing smiles), but I think you could pull off something more interesting perhaps by setting the timeline before most of the personalities became Smith(')s or by simply finding a way not to reduce the most interesting elements of the original game.